GENICULAR ARTERY EMBOLIZATION (GAE)
A Minimally Invasive Option for Chronic Knee Pain from Osteoarthritis. GAE is a minimally invasive procedure that reduces chronic knee pain by targeting and blocking small abnormal blood vessels (genicular arteries) that contribute to joint inflammation.
Contact AVC to see if you are a candidate for Genicular Artery Embolization (GAE).
Overview of Genicular Artery Embolization (GAE)
Knee pain is extremely common, and as we age, the most common cause is osteoarthritis, better known as “arthritis.” Over the course of our lives, degeneration of the joints happens resulting in stiffness, swelling, and pain. For many people, medications, physical therapy, bracing, and injections have limited or temporary results.
If you experience:
- Persistent knee pain, especially during activity (climbing stairs, getting out of a chair, standing, etc).
- Swelling or stiffness that limits mobility
- Pain that doesn’t improve with other therapies
- You want to avoid surgery
- You have persistent pain after knee replacement
Then you likely would benefit from Genicular Artery Embolization (GAE), a non-surgical treatment for knee pain.
What Is Genicular Artery Embolization?
New research shows that knee pain is caused from inflammation of abnormal blood vessels and reducing these abnormal blood vessels can improve pain and mobility.
GAE is a minimally invasive procedure that reduces knee pain by blocking tiny abnormal blood vessels (genicular arteries) that contribute to joint inflammation.
In arthritis, abnormal vessel growth in the knee can lead to:
- Chronic inflammation
- Irritation of the surrounding nerves
- Joint pain
- Swelling
GAE uses advanced imaging to guide a small catheter into these abnormal vessels and inject medication to block them, reducing inflammation and pain without altering joint structure.
We perform this procedure in our office with a local anesthetic, it takes less than an hour, and is extremely safe.
Benefits of Genicular Artery Embolization
- Non-surgical
- No cutting, implants, or general anesthesia
- Avoids knee replacement
- Performed under local anesthesia and a light sedative
- Preserves natural knee structure
- Quick recovery – Patients return to normal activity the following day
- Long-term pain relief
- Results often last for years
- Can be used in mild to severe arthritis
Why Choose Advanced Vascular Centers?
- Board-certified interventional vascular specialists
- Evidence based customized care plan focused on long-term pain relief
- Personable and dedicated staff (see our Google reviews!)
- No need to go to the hospital
- Advanced imaging technology and equipment
Patient Flow
At Advanced Vascular Centers, GAE is performed by expert interventionalists following the original Okuno method, below you can find information on the individual steps we take for each patient.
- Pre-procedural consultation
As a patient, you will meet with the doctor beforehand and we review your symptoms, exam findings, prior medical record, and prior imaging (X-ray, MRI, or CT) to confirm your diagnosis. We discuss your case in depth and make sure you have a complete understanding of the procedure.
- Procedure day
- Check in – One to two hours beforehand to prepare and to review your medical history.
- Numbing medication – Local numbing medication is given at the access site (usually the groin or ankle). A mild relaxing medication can be given to make you comfortable as well. A nurse will be monitoring your blood pressure as a precaution while our doctor is performing the procedure.
- Access – A tiny IV needle accesses the blood vessel and a catheter is inserted and guided into the genicular arteries supplying the knee joint (see video).
- Treatment – Once the catheter is in the correct position, medication is injected to block the abnormal vessels. The normal blood vessels supplying the knee joint remain open.
- Completion – The catheter is removed, and a small bandage is applied—no stitches.
- Recovery
- Rest for approximately 30 minutes after the procedure.
- You go home about 1 hour after the procedure.
- Resume light activity the next day.
- Full activity will resume in about 1 week.
- Pain relief typically begins within 2–4 weeks and can be sustained for 2+ years.
- Follow-up
- 1 month after the procedure we see you in our clinic to check how you are feeling after the treatment.
- If you are progressing as expected, no further follow up is needed.
- We love hearing and sharing in our patients’ success so we encourage all our patients to follow up as needed!
What Results Can I Expect?
GAE provides meaningful relief for most people with knee pain:
- Reduced knee pain with walking, climbing stairs, hiking, and other activities
- Decreased stiffness and swelling
- Improved mobility and function
- Lower dependence on pain medications or injections
- Delays the need for total knee replacement
Studies show that the majority of patients report long lasting pain reduction after GAE, especially in early- to mid-stage arthritis.
Is Genicular Artery Embolization Right for Me?
You may be a good candidate if you:
- Have knee osteoarthritis that causes pain or limits mobility
- Tried injections, therapy, or medications without relief
- Are not ready for or cannot undergo total knee replacement
- Want a non-surgical solution with virtually zero recovery time
Our team will evaluate your condition and imaging to see if GAE is appropriate for you.
Risks & Complications
GAE is an extremely safe and well-tolerated procedure, but as with any medical treatment, there are side effects.
Common, mild side effects:
- Bruising or soreness at the access site
- Temporary knee stiffness or discomfort, for less than 1 week
- Minor skin discoloration that improves in a couple of months
FAQS
Will insurance cover GAE?
Yes. Our staff will help verify your benefits and review any out-of-pocket costs before scheduling.
Both of my knees hurt, can you treat them both?
Yes, we typically treat the worst knee first, then treat the other knee on another day.
What is Genicular Artery Embolization (GAE)?
Embolization means targeting blockage of a blood vessel for a treatment. Genicular arteries are the blood vessels that supply the knee. So GAE is a non-surgical procedure that treats knee pain from arthritis by blocking abnormal blood vessels that contribute to inflammation in the joint.
Who qualifies for GAE?
Since it is such a low risk procedure, nearly all patients are candidates for GAE if they have not found relief from medications, injections, or physical therapy. It’s also suitable for people who cannot undergo knee surgery or wish to delay it.
Is GAE painful?
No. Most patients are surprised how easy the procedure is and how comfortable they are. The procedure uses local anesthesia (like the dentist), and most patients report no discomfort.
How long does the procedure take?
The procedure usually takes less than 1 hour. You’ll recover briefly in our center and then go home about 1 hour after the procedure.
When will I feel better?
Most patients experience pain relief within 2 to 4 weeks, with long term pain relief.
How long do the results last?
For many, the benefits of GAE last years. While it doesn’t reverse arthritis, it treats the inflammation and pain source, which can significantly improve quality of life.
Can GAE be repeated?
Yes, rarely patients will need a repeat treatment 1-2 years after initial GAE.
Are there risks?
GAE is extremely safe and low risk. There have never been any major complications associated with GAE.
If I need a knee replacement in the future, can I still do GAE?
Yes, if your knee pain returns you can opt for another GAE or proceed to a knee replacement if needed.
Please contact our office to schedule a consultation to see if GAE is right for you.
TESTIMONIALS
References
- Rada Abussa, Aleksandar Jeremic, Bridging the Gap between Injections and Surgery: Meta-Analysis of Genicular Artery Embolization in Knee Osteoarthritis, Academic Radiology, 2025,ISSN 1076-6332, https://doi.org/10.1016/j.acra.2025.05.011.
- Taslakian B, Miller LE, Mabud TS, Macaulay W, Samuels J, Attur M, Alaia EF, Kijowski R, Hickey R, Sista AK. Genicular artery embolization for treatment of knee osteoarthritis pain: Systematic review and meta-analysis. Osteoarthr Cartil Open. 2023 Feb 6;5(2):100342. doi: 10.1016/j.ocarto.2023.100342. PMID: 36865988; PMCID:MC9971280.
- Chlorogiannis, DD., Vasilopoulou, A., Konstantinidis, C.I. et al. Knee pain improvement after genicular artery embolization for the management of knee osteoarthritis: an updated systematic review and meta-analysis of 21 studies. Radiologie 64 (Suppl 1), 32–46 (2024). https://doi.org/10.1007/s00117-024-01388-9
- Badar W, Anitescu M, Ross B, Wallace S, Uy-Palmer R, Ahmed O. Quantifying Change in Perfusion after Genicular Artery Embolization with Parametric Analysis of Intraprocedural Digital Subtraction Angiograms. J Vasc Interv Radiol. 2023 Dec;34(12):2190-2196. doi: 10.1016/j.jvir.2023.08.041. Epub 2023 Sep 9. PMID: 37673399.
- Bow Wang, Ta-Wei Tai, Keng-Wei Liang, Chien-Kuo Wang, Yi-Sheng Liu, Ming-Tung Huang, Chih-Wei Chang, Short-Term Effects of Genicular Artery Embolization on Symptoms and Bone Marrow Abnormalities in Patients with Refractory Knee Osteoarthritis, Journal of Vascular and Interventional Radiology, Volume 34, Issue 7, 2023, Pages 1126-1134.e2, ISSN 1051-0443, https://doi.org/10.1016/j.jvir.2023.02.028